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Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351 – –

Correspondence from The New England Journal of Medicine — Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351



The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.429 (also called CAL.20C or 542R.V1), first identified in California,1 is spreading rapidly in the United States and has been found in at least 25 other countries (see updates at This variant contains three spike mutations that are major targets for neutralizing antibodies; one mutation (L452R) is located in the receptor-binding motif, and another (W152C) in the N-terminal domain…

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